Laboratory for Experimental Cardiac Electrophysiology

The general goal of the Laboratory for Experimental Cardiac Electrophysiology at Freiburg University - the Odening Lab - is to advance the mechanistic understanding of arrhythmogenesis in arrhythmia disorders. Using different transgenic animal models of human inherited arrhythmogenic diseases such as long-QT and short-QT syndrome our laboratory aims at elucidating how the arrhythmogenic phenotype is modulated by extrinsic and intrinsic factors - such as hormones or drugs - and electro-mechanical interactions in the heart.


The Odening Lab will move to Bern University & Inselspital!
Our paper on the first transgenic rabbit animal model for short QT syndrome is published in the European Heart Journal (PubMed).
Editorial to our paper (Odening et al. Eur Heart J 2019) by Carol Ann Remme: “Down the rabbit hole: deciphering the short QT syndrome” (PubMed).
Editorial to our paper (Ziupa et al. Int J Cardiol 2018) by Kristina Haugaa: “Cardiac electrical and mechanical alterations - united in the long QT syndrome”.
Editorial to our paper (Brado et al. Heart Rhythm 2017) by Elena Arbelo: “Another piece of the puzzle: Assessment of mechanical dispersion by magnetic resonance in long QT syndrome”.
A. Castiglione's project on genotype-specific beneficial effects of DHA in LQTS was awarded in the "Young Investigator Award Competition Arrhythmia" of the German Cardiac Society 2017.
T. Hornyik's project on double-transgenic LQT2-5 rabbits as novel tool for pro-arrhythmia detection was awarded the "Best Translational Poster Award" at the International Academia of Cardiovascular Science 2016 and was awarded the “Best Poster in Biomedical Sciences”, International Academy of Cardiovascular Sciences North America 2017.
The special issue of Progress in Biophysics and Molecular Biology on 'Past, present, and future of rabbit model systems as experimental and computational drivers of progress in cardiac biophysics' edited by K Odening and P Kohl has been published.
Our lab became part of the newly established Institute for Experimental Cardiovascular Medicine at the University Heart Center, Freiburg.
Editorial to our paper (Odening et al. Heart Rhythm 2013) by Peter Kohl: “From ion channel to organismic phenotype: an example of integrative translational research into cardiac electro-mechanics”
Editorial to our paper (Bodi et al. J Cardiovasc Electrophysiol 2013) by H Abriel and JS Rougier: “β-Blockers in Congenital Short-QT Syndrome as Ion Channel Blockers”
Our paper on the effect of sex hormones in LQTS (Odening et al. Heart Rhythm 2012) has been selected as “Heart Rhythm outstanding basic science article 2012” (Press release, in German)
Editorial to our paper (Odening et al. Heart Rhythm 2012) by Arthur Moss: “Sex hormones and ventricular tachyarrhythmias in LQTS: new insights regarding antiarrhythmic therapy”
Feature on PI Katja Odening and the "Margarete von Wrangell Award" in the European Perspectives of Circulation.