Laboratory for Experimental Cardiac Electrophysiology
 
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Publications
 
 

Publications


2019

[58] I. Bodi, E.M. Wuelfers, A. Castiglione, S. Perez-Feliz, M. Zehender, M. Brunner, C. Bode, G. Seemann, K.E. Odening. Comment: Postpartum hormones oxytocin and prolactin cause pro-arrhythmic prolongation of cardiac repolarization in long QT syndrome type 2 - Authors' reply. EP Europace 2019, 21(7):1141-1142.   [ PubMed ]

[57] C. Koentges, M.C. Cimolai, K. Pfeil, D. Wolf, T.O. Marchini, A. Tarkhnishvili, M.M. Hoffmann, K.E. Odening, P. Diehl, C. von zur Mühlen, S. Alvarez, C. Bode, A. Zirlik, H. Bugger. Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis. J Mol Cell Cardiol 2019, 133:138-147.   [ PubMed ]

[56] I. El-Battrawy, K. Schlentrich, J. Besler, V. Liebe, R. Schimpf, S. Lang, K.E. Odening, C. Wolpert, X. Zhou, M. Borggrefe, I. Akin. Sex-differences in Short QT Syndrome: a systematic literature review and pooled analysis. Eur J Prev Cardiol 2019, May 24:2047487319850953.   [ PubMed ]

[55] I. El-Battrawy, J. Besler, U. Ansari, V. Liebe, R. Schimpf, E. Tülümen, B. Rudic, S. Lang, K.E. Odening, L. Cyganek, C. Wolpert, X. Zhou, M. Borggrefe, I. Akin I. Long-term follow-up of implantable cardioverter-defibrillators in Short QT syndrome. Clin Res Cardiol 2019, 108(10):1140-1146.   [ PubMed ]

[54] I. Bodi*, J. Sorge*, A. Castiglione*, S.M. Glatz, E.M. Wuelfers, G. Franke, S. Perez Feliz, G. Koren, M. Zehender, H. Bugger, G. Seemann, M. Brunner, C. Bode, K.E. Odening. Postpartum hormones oxytocin and prolactin cause pro-arrhythmic prolongation of cardiac repolarization in long QT syndrome type 2. EP Europace 2019, 21(7):1126-1138.   [ PubMed ]

[53] K.E. Odening, I. Bodi, G. Franke, R. Rieke, A. Ryan de Medeiros, S. Perez-Feliz, H. Furniss, L. Mettke, K. Michaelides, C.N. Lang, J. Steinfurt, N.D. Pantulu, D. Ziupa, M. Menza, M. Zehender, H. Bugger, R. Peyronnet, J. Behrends, Z. Doleschall, A. zur Hausen, C. Bode, G. Jolivet, M. Brunner. Transgenic short-QT syndrome 1 rabbits mimic the human disease phenotype with QT/APD shortening in the atria and ventricles and increased VT/VF inducibility. Eur Heart J 2019, 40(10):842-853.   [ PubMed ]

  Related editorial by Carol Ann Remme, University of Amsterdam: Down the rabbit hole: deciphering the short QT syndrome. Eur Heart J 2019, 40(10):854-856.   [ PubMed ]

[52] K.E. Odening, S. Deiß, D. Dilling-Boer, M. Didenko, U. Eriksson, S. Nedios, F.S. Ng, I. Roca Luque, P. Sanchez Borque, K. Vernooy, A.P. Wijnmaalen, H. Yorgun. Mechanisms of sex differences in atrial fibrillation: role of hormones and differences in electrophysiology, structure, function, and remodelling. Europace 2019, 21:366–376.   [ PubMed ]

[51] D. Thomas, A. Goette, T. Christ, L. Fabritz, M. Hammwöhner, J. Heijman, J. Kockskamper, D. Linz, K.E. Odening, P. Schweizer, R. Wakili, N. Voigt. German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management. Clin Res Cardiol 2019, 108(6):577-599.   [ PubMed ]

[50] D. Ziupa, M. Menza, S. Koppermann, K.R. Moss, J. Beck, G. Franke, S. Perez Feliz, M. Brunner, S. Mayer, H. Bugger, G. Koren, M. Zehender, B.A. Jung, G. Seemann, D. Foell, C. Bode, K.E. Odening. Electro-mechanical (dys-)function in long QT syndrome type 1. Int J Cardiol 2019, 274:144-151.   [ PubMed ]

  Related editorial by Kristina Haugaa, Oslo University: Cardiac electrical and mechanical alterations - united in the long QT syndrome. Int J Cardiol 2019, 274:190-191.   [ Publisher ]


2018

[49] C.R. Glöcklhofer, J. Steinfurt, G. Franke, A. Hoppmann, T. Glatschnig, S. Perez-Feliz, S. Alter, J. Fischer, M. Brunner, P.P. Rainer, A. Köttgen, C. Bode, K.E. Odening. A novel LMNA nonsense mutation causes two distinct phenotypes of cardiomyopathy with high risk of sudden cardiac death in a large five-generation family. Europace 2018, 20:2003-2013.   [ PubMed ]

[48] K.E. Odening. Another step towards a mechanism-based, subtype-specific therapy in long QT syndrome. Int J Cardiol 2018, 263:67-68.   [ PubMed ]

[47] K.E. Odening, D. Ziupa. Transgenic animal models of cardiac channelopathies – benefits and limitations. Channelopathies in Heart Disease 2018, Springer Publishing, Heidelberg.   [ Publisher ]

[46] J. Steinfurt, K.E. Odening, B. Stiller, T.S. Faber, C. Bode, S. Asbach, J. Biermann. Fascicular parasystole with recurrent syncope. Eur Heart J - Case Reports 2018; 2(1):1-4.   [ Publisher ]

[45] F. Dressler, J. Brado, K.E. Odening. Electro-mechanical heterogeneity in the heart: A key to long QT syndrome? Herzschrittmacherther Elektrophysiol 2018, 29(1), 43-47.   [ PubMed ]


2017

[44] C. Koentges, M. Pepin, C. Müsse, K. Pfeil, M.M. Hoffmann, K.E. Odening, S. Sossalla, A. Zirlik, L. Hein, C. Bode, A. Wende, H. Bugger. Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans. Basic Res Cardiol 2017;113(1):8.   [ PubMed ]

[43] F.F. Dreßer, I. Bodi, M. Menza, R. Moss, H. Bugger, C. Bode, J.C. Behrends, G. Seemann, K.E. Odening. Interregional electro-mechanical heterogeneity in the rabbit myocardium. Prog Biophys Mol Biol 2017, 14(9):1388-1397.   [ PubMed ]

[42] J. Brado, M.J. Dechant, M. Menza, A. Komancsek, C.N. Lang, H. Bugger, B. Stiller, D. Foell, B.A. Jung, C. Bode, K.E. Odening. Phase contrast MRI reveals regional, transmural, and base-to-apex dispersion of mechanical dysfunction in LQTS patients. Heart Rhythm 2017, 14(9):1388-1397.   [ PubMed ]

  Related editorial by Elena Arbelo, University of Barcelona: Another piece of the puzzle: Assessment of mechanical dispersion by magnetic resonance in long QT syndrome. Heart Rhythm 2017, 14(9):1398-99.   [ Publisher ]

[41] C.N. Lang, J. Steinfurt, K.E. Odening. How can we avoid sport-related sudden cardiac death in children with congenital channelopathies? Recommendations for sportive activities. Herz Cardiovascular Diseases 2017, 42(2):162-170.   [ PubMed ]

[40] S.C. Gruenert, I. Bodi, K.E. Odening. Possible pathomechanisms for sensorineural hearing loss and deafness in patients with propionic acidemia. Orphanet J Rare Dis 2017, 12(1):30.   [ Open Access ]  [ PubMed ]

[39] C. Gimpel, B.A. Jung, S. Jung, J. Brado, D. Schwendinger, M. Pohl, K.E. Odening, J. Geiger, R. Arnold. Magnetic tesonance tissue phase mapping (TPM) demonstrates altered left ventricular diastolic function in children with chronic kidney disease. Pediatr Radiol 2017, 47: 169-177.   [ PubMed ]

[38] U. Ravens, K.E. Odening. Atrial fibrillation: Therapeutic potential of atrial K+ channel blockers. Pharmacol Ther 2017; 176:13-21.   [ PubMed ]


2016

[37] K.E. Odening, P. Kohl. Follow the white rabbit: Experimental and computational models of the rabbit heart provide insights into cardiac (patho-) physiology. Prog Biophys Mol Biol 2016, 121(2):75-6.   [ PubMed ]

[36] C.N. Lang, G. Koren, K.E. Odening. Transgenic rabbit models to investigate the cardiac ion channel diseases long QT syndrome. Prog Biophys Mol Biol 2016, 121(2):142-56.   [ PubMed ]

[35] Z. Bosze, P. Major, I. Baczko, K.E. Odening, L. Bodrogi, L. Hiripi, A. Varro. The potential impact of new generation transgenic methods on creating rabbit models of cardiac diseases. Prog Biophys Mol Biol 2016, 2016;121(2):123-30.   [ PubMed ]

[34] K.E. Odening, P. Kohl. It is difficult to make predictions, especially about the future:* thoughts about forecasting cardiotoxicity of pharmacological interventions. Prog Biophys Mol Biol 2016, 121(1):1-2   [ PubMed ]

[33] P. Major, I. Baczko, L. Hipiri, K.E. Odening, V. Juhasz, Z. Kohajda, A. Horvath, G. Seprenyi, M. Kovacs, J. Prorok, B. Ordog, Z. Doleschall, S. Nattel, A. Varro, Z. Bosze. A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of KCNE1 gene. Br J Pharmacol 2016, 173(12):2046-61.   [ PubMed ]

[32] I. Bodi, S.C. Gruenert, N. Becker, S. Stoelzle-Feix, U. Spiekerkoetter, M. Zehender, C. Bode, K.E. Odening. Mechanisms of acquired long-QT syndrome in patients with propionic acidemia. Heart Rhythm 2016, 13(6):1335-45.   [ PubMed ]

[31] C.N. Lang, M. Menza, S. Jochem, G. Franke, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, B.A. Jung, D. Foell, C. Bode, K.E. Odening. Electro-mechanical dysfunction in long QT syndrome: role for arrhythmogenic risk prediction and modulation by sex and sex hormones. Progress in Biophysics and Molecular Biology 2016, 120(1-3):255-69.   [ PubMed ]

[30] K.E. Odening, G. Koren, M. Kirk. Normalization of QT Interval duration in a long QT syndrome patient during pregnancy and the postpartum period due to sex hormone effects on cardiac repolarization. Heart Rhythm Case Reports 2016, 2(3):223-227    [ Open Access ]   [ PubMed ]

[29] K.E. Odening. Another jigsaw piece in the complex picture of hormonal regulation of cardiac repolarization. Eur Heart J 2016, 37(7):651-3.   [ PubMed ]

[28] C. Koentges, K. Pfeil, M. Meyer-Steenbuck, A. Lothar, M. Hoffmann, K.E. Odening, L. Hein, C. Bode, H. Bugger. Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3. Can J Physiol Pharmacol 2016, 94(1):72-80.   [ PubMed ]


2015

[27] C. Koentges, A. König, K. Pfeil, M.E. Hölscher, T. Schnick, A.R. Wende, A. Schrepper, M.C. Cimolai, S. Kersting, M.M. Hoffmann. J. Asal, M. Osterholdt, K.E. Odening, T. Doenst, L. Hein, E.D Abel, C. Bode, H. Bugger. Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1. Basic Res Cardiol 2015, 110(4):495.   [ PubMed ]

[26] C. Koentges, K. Pfeil, T. Schnick, S. Wiese, R. Dahlbock, M.C. Cimolai, M. Meyer-Steenbuck, K. Cenkerova, M.M. Hoffmann, C. Jaeger, K.E. Odening, B. Kammerer, L. Hein, C. Bode, H. Bugger. SIRT3 deficiency impairs mitochondrial and contractile function in the heart. Basic Res Cardiol 2015, 110(4):493.   [ PubMed ]

[25] J. Steinfurt, K.E. Odening. Early repolarization: a risk factor in Brugada syndrome. J Am Coll Cardiol 2015, 66(2):205-6.   [ PubMed ]

[24] J. Steinfurt, C. Bode, K.E. Odening. Brugada syndrome − diagnosis, risk stratification and therapy. Dtsch Arztebl Int 2015, 112:394–401.   [ PubMed ]


2014

[23] D. Terentyev, C. Rees, W. Li, L.L. Cooper, H.K. Jindal, X. Peng, Y. Lu, R. Terentyeva, K.E. Odening, J. Daley, K. Bist, B.-R. Choi, A. Karma, G. Koren. Hyperphosphorylation of RyRs underlies triggered activity in transgenic rabbit model of LQT2 syndrome. Circ Res 2014, 115(11):919-28.   [ PubMed ]

[22] J. Steinfurt, M.J. Dechant, D. Boeckelmann, S. Zumhagen, B. Stiller, E. Schulze-Bahr, C. Bode, K.E. Odening. High-dose flecainide with low-dose beta-blocker therapy in catecholaminergic polymorphic ventricular tachycardia: a case report and review of the literature. J Cardiol Cases 2014, 174(2):e29-31.   [ Free Text ]

[21] D. Ziupa*, J. Beck*, G. Franke, S. Perez Feliz, M. Hartmann, G. Koren, C. Bode, M. Zehender, M. Brunner, K.E. Odening. Pronounced effects of E4031 and erythromycin on APD, spatial APD dispersion and triangulation in transgenic long-QT type 1 rabbits. Plos One 2014, 9(9):e107210. (* shared authorship)   [ PubMed ]   [ Free Text ]

[20] K.E. Odening, G. Koren. How do sex hormones modify arrhythmogenesis in LQTS? - Sex hormone effects on arrhythmogenic substrate and on triggered activity. Heart Rhythm 2014, 11(11):2107-15.   [ PubMed ]

[19] J. Steinfurt, J. Biermann, M. Hartmann, F. Schlurmann, K.E. Odening, C. Bode, S. Asbach. Remote ICD-Monitoring in detection and follow-up of idiopathic ventricular fibrillation: Implications for the clinical follow-up of IVF patients. Int J Cardiol 2014, 174(2): e29-31.   [ PubMed ]


2013

[18] K. E. Odening, B. A. Jung, C. N. Lang, R. Cabrera Lozoya, D. Ziupa, M. Menza, J. Relan, G. Franke, S. Perez Feliz, G. Koren, M. Zehender, C. Bode, M. Brunner, M. Sermesant, D. Foell. Spatial correlation of action potential duration and diastolic dysfunction in transgenic and drug-induced LQT2 rabbits. Heart Rhythm 2013, 10(10):1533-41.   [ PubMed ]

  Related editorial by Peter Kohl, Imperial College: From ion channel to organismic phenotype: an example of integrative translational research into cardiac electro-mechanics. Heart Rhythm 2013, 10(10):1542-3.   [ Publisher ]

[17] I. Bodi, G. Franke, N. D. Pantulu, K. Wu, S. Perez-Feliz, C. Bode, M. Zehender, A. Z. Hausen, M. Brunner, K. E. Odening. Differential effects of beta-adrenoceptor blockers Carvedilol and Metoprolol on SQT1- and SQT2-causing mutant channels. J Cardiovasc Electrophys 2013, 24(10):1163-71.   [ PubMed ]

   Related editorial by Hugues Abriel and Jean-Sebastien Rougier, University of Bern: β-Blockers in congenital short-QT syndrome as ion channel blockers. J Cardiovasc Electrophysio 2013, 24(10):1172-4.   [ Publisher ]

[16] K. E. Odening, Ch. Bode, M. Zehender, M. Brunner. Sex differences and sex hormone effects in long-QT syndrome – what can we learn from rabbit models? Review. Clin Res Cardiol Suppl 2013, 8(1):14-19.   [ Publisher ]

[15] K. E. Odening, M. Brunner. Risk stratification in long QT syndrome: Are we finally getting closer to a mutation-specific assessment of an individual patient's arrhythmogenic risk? Heart Rhythm 2013, 10(5):726-7.   [ PubMed ]


2012

[14] B. Jung*, K. E. Odening*, E. Dall'Armellina*, D. Foell, M. Menza, M. Markl, J. E. Schneider. A quantitative comparison of regional myocardial motion in mice, rabbits and humans using in-vivo phase contrast CMR. J Cardiovasc Magn Reson 2012, 14:87. (* shared authorship)   [ PubMed ]  [ Free Text ]

[13] K. E. Odening, B.-R. Choi, G. Koren. Sex hormones and cardiac arrest in long QT syndrome: Does progesterone represent a potential new antiarrhythmic therapy? Heart Rhythm 2012, 9(7):1150-2.   [ PubMed ]

[12] V. Duranthon, N. Beaujean, M. Brunner, K. E. Odening, A. N. Santos, I. Kacskovics, L. Hiripi, E. J. Weinstein, Z. Bosze. On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools. Transgenic Res 2012, 21:699-713.   [ PubMed ]

[11] L. L. Cooper*, K. E. Odening*, M.-S. Hwang, L. Chaves, L. Schofield, C. A. Taylor, A. S. Gemignani, G. Mitchell, B.-R. Choi, J. F. Forder, G. Koren. Electromechanical and structural alterations in the aging rabbit heart and aorta. AJP Heart Circ Physiol 2012, 302(8):H1625-35. (* shared authorship)   [ PubMed ]   [ Free Text ]

[10] K. E. Odening, B.-R. Choi, G. X. Liu, K. Hartmann, O. Ziv, L. Chaves, L. Schofield, J. Centracchio, M. Zehender, X. Peng, M. Brunner, G. Koren. Estradiol promotes sudden cardiac death in transgenic long-QT type 2 rabbits while progesterone is protective. Heart Rhythm 2012, 9(5):823-32.  [ PubMed ]   Heart Rhythm outstanding basic science article 2012

   Related editorial by Arthur J. Moss, University of Rochester: Sex hormones and ventricular tachyarrhythmias in LQTS: new insights regarding antiarrhythmic therapy. Heart Rhythm 2012, 9(5):833-834.  [ PubMed ]


2011 and earlier

[9] B. H. Bentzen, S. Bahrke, K. Wu, A. P. Larsen, K. E. Odening, G. Franke, J. Biermann, G. Koren, M. Zehender, C. Bode, M. Grunnet, M. Brunner. Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits. J Cardiovasc Pharmacol 2011, 57(2):223-30.  [ PubMed ]

[8] J. Biermann, K. Wu, K. E. Odening, S. Asbach, G. Koren, X. Peng, M. Zehender, C. Bode, M. Brunner. Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo. Eur J Pharmacol 2011, 650(1):309-16.  [ PubMed ]  [ Free Text ]

[7] K. E. Odening*, M. Kirk*, M. Brunner*, O. Ziv*, P. Lorvidhaya, G.X. Liu, L. Schofield, L. Chaves, X. Peng, M. Zehender, B.-R. Choi, G. Koren. Electrophysiological studies of transgenic long QT type 1 and type 2 rabbits reveal genotype-differences in ventricular refractoriness and His-Purkinje conduction. AJP Heart Circ Physiol 2010, 299(3):H643-55.  [ PubMed ]   [ Free Text ]

[6] O. Ziv, E. Morales, Y.-K. Song, X. Peng, K. E. Odening, A. E. Buxton, A. Karma, G. Koren, B.-R. Choi. Origin of complex behavior of spatially discordant alternans in transgenic rabbit model of LQT2. J Physiol 2009, 587(Pt 19):4661-80.   [ PubMed ]   [ Free Text ]

[5] K. E. Odening, J.M. Nerbonne, C. Bode, M. Zehender, M. Brunner. In vivo effect of the selective elimination of Ito,f due to a dominant negative Kv4.2 loss-of-function mutation on atrial refractoriness and atrial fibrillation in mice. Circ J 2009, 73(3):461-7.   [ PubMed ]  [ Free Text ]

[4] K. E. Odening, W. Li, R. Rutz, S. Laufs, S. Fruhauf, Z. Fishelson, M. Kirschfink. Enhanced complement resistance of drug-selected P-glycoprotein positive multidrug resistant ovarian carcinoma cells. Clin Exp Immunol 2009, 155(2): 239-48.  [ PubMed ]  [ Free Text ]

[3] K. E. Odening, O. Hyder, L. Chaves, L. Schofield, M. Brunner, M. Kirk, M. Zehender, X. Peng, G. Koren. Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization. AJP Heart Circ Physiol 2008, 295:H2264-72.  [ PubMed ]  [ Free Text ]

[2] M. Brunner*, X. Peng*, G.X. Liu*, X.Q. Ren, O. Ziv, B-R Choi, R. Mathur, M. Hajjiri, K. E. Odening, E. Steinberg, E. Folco, A. Pringa, J. Centracchio, R. Macharzina, T. Donahay, L. Schofield, N. Rana, M. Kirk, G. Mitchel, A. Poppas, M. Zehender, G. Koren. Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome. J Clin Invest 2008, 118(6):2246-2259.  [ PubMed ]  [ Free Text ]

[1] A. Geibel, M. Olschewski, M. Zehender, M. Wilsch, K. E. Odening, F. Heinrich, W. Kasper and S. Konstantinidis. Possible gender-related differences in the risk-to-benefit ratio of thrombolysis for acute submassive pulmonary embolism. Am J Cardiol 2007, 99(1):103-7.  [ PubMed ]



Reviews in German (Übersichtsartikel)

[4] A. Castiglione, K.E. Odening. QT-Verlängerung - Was nun? Deutsche Medizinische Wochenschrift 2020

[3] J. Brado, K.E. Odening. Familiäre Arrhythmiesyndrome mit strukturell normalen Herzen / Familial arrhythmia disorders with structurally normal hearts. Aktuelle Kardiologie 2018, 7:190-196.

[2] K. E. Odening. Das LQTS - Risikofaktoren, Diagnostik und Therapie. Herzkreislauf Journal 2010, 7:12-14.

[1] K. E. Odening. Ventrikuläre Arrhythmien bei Frauen - welche Rolle spielen Hormone? MedReview 2009, (10) 7: 6-7.



Selected Conference Contributions

2019

R. Lewetag, T. Hornyik, S. Jacobi, R. Moss, C. Zgierski-Johnston, M. Menza, S. Perez-Feliz, C. Bode, G. Seemann, K.E. Odening. Electro-mechanical heterogeneity and electro-mechano-electrical interactions in healthy and drug-induced LQTS rabbit hearts. DGK Herbsttagung - Basic Science Meeting, Oktober 2019, Berlin.

T. Hornyik, A. Castiglione, G. Franke, S. Perez-Feliz, P. Major, L. Hiripi, G. Koren, Z. Bosze, A. Varro, M. Brunner, C. Bode, I. Baczko, K.E. Odening.Transgenic LQT5, LQT2 and LQT2-5 rabbit models with decreased repolarization reserve for better prediction of drug induced pro-arrhythmic side effects. DGK Jahrestagung, April 2019, Mannheim. Oral presentation.

I. Bodi, P. Kreifels, G. Franke, S. Perez-Feliz, A. Castiglione, D. Ziupa, M. Brunner, C. Bode, K.E. Odening. Oxytocin blocks IKs and IK1 and exerts harmful cardiac repolarization prolonging effects particularly in context of IKr-blocker induced drug-induced LQTS. DGK Jahrestagung, April 2019, Mannheim. Oral presentation.

K. Michaelides, L.Mettke, I. Bodi, S. Perez-Feliz, M. Brunner, C. Bode, K.E. Odening. Carnitine exerts beneficial QT- / APD prolonging effects in vivo and on ex vivo whole heart and cellular levels in transgenic short QT syndrome 1 rabbits. DGK Jahrestagung, April 2019, Mannheim. Oral presentation.

T. Hornyik, A. Castiglione, G. Franke, S. Perez-Feliz, P. Major, L. Hiripi, G. Koren, Z. Bosze, A. Varro, M. Brunner, C. Bode, I. Baczko, K.E. Odening.Transgenic LQT5, LQT2 and LQT2-5 rabbit models with decreased repolarization reserve for more reliable prediction of drug induced ventricular arrhythmias. EHRA / EWGCCE Meeting, Mar 2019, Lisbon.

P. Kreifels, I. Bodi, G. Franke, S. Perez-Feliz, A. Castiglione, D. Ziupa, M. Brunner, C. Bode, K.E. Odening. Oxytocin blocks IKs and IK1 - thus exerting harmful cardiac repolarization prolonging effects particularly in context of drug-induced LQTS. EHRA / EWGCCE Meeting, Mar 2019, Lisbon.

2018

A. Castiglione, T. Hornyik, G. Franke, S. Perez-Feliz, Z. Bősze, G. Koren, A. Varró, M. Zehender, M. Brunner, C. Bode, I. Baczkó, K.E. Odening. Docosahexaenoic acid acts as QT-shortening agent with genotype-specific beneficial effects in transgenic LQT1, LQT2, LQT5 and LQT2-5 rabbit models. Annual Meeting of the European Society of Cardiology, Aug 2018, Munchen, Germany. Best Poster Session.

P. Kreifels, G. Franke, S. Perez-Feliz, I. Bodi, A. Castiglione, D. Ziupa, M. Brunner, C. Bode, K.E. Odening. Oxytocin has harmful cardiac repolarization prolonging effects - particularly in context of drug-induced LQTS. Annual Meeting of the European Society of Cardiology, Aug 2018, Munchen, Germany. Oral presentation.

I. Bodi, J. Sorge, S. Glatz, A. Castiglione, G. Franke, S. Perez-Feliz, G. Koren, M. Zehender, M. Brunner, C. Bode, K.E. Odening.. Oxytocin and prolactin prolong cardiac repolarization in long QT syndrome type 2 by altering KCNQ1/IKs, Cav1.2 and RyR2 expression and function. 84th Annual Meeting of the German Society of Cardiology, April 2018, Mannheim, Germany.

P. Kreifels, J. Steinfurt, D. Ziupa1, J. Brado, P. Schweizer, I. Baczko, C. Bode, K.E. Odening. ECG markers indicating temporal heterogeneity in repolarization as useful tools for arrhythmic risk prediction in long QT syndrome. 84th Annual Meeting of the German Society of Cardiology, April 2018, Mannheim, Germany.

E.M. Wülfers, G. Seemann, K. Krieger, C. Lenz, B. Keweloh, P. Kohl, C. Bode, K. E. Odening, J. Steinfurt. Whole heart computer modeling of coved-type ECG in Brugada syndrome: further evidence for delayed depolarization in the right ventricular outflow tract. 84th Annual Meeting of the German Society of Cardiology, April 2018, Mannheim, Germany.

2017

P. Kreifels, G. Franke, S. Perez-Feliz, I. Bodi, C. Bode, K.E. Odening. Good feeling, bad heart? . Ambiguity of "cuddling" hormone oxytocin in therapeutic use due to repolarization prolonging effects in the context of anti-psychotic and anti-depressant drug-treatment. 41th Meeting of the ESC Working Group on Cardiac Cellular Electrophysiology, June 2017, Vienna, Austria.

A. Castiglione, T. Hornyik, G. Franke, S. Perez-Feliz, Z. B.sze, G. Koren, A. Varró. Brunner, C. Bode, I. Baczkó.E. Odening. Genotype-specific beneficial QT-shortening effects of docosahexaenoic acid in transgenic LQT2, LQT5 and LQT2-5 rabbit models. 83th Annual Meeting of the German Society of Cardiology, April 2017, Mannheim, Germany. Young Investigator Award Finalist. Oral presentation.

K.E. Odening, I. Bodi, R. Rieke, G. Franke, A. Ryan de Medeiros, S. Perez-Feliz, A. zur Hausen, G. Jolivet, C. Bode, M. Brunner. Electrico-Mechanical Remodeling in Transgenic Short QT 1 Rabbits. .38th Annual Scientific Sessions of the Heart Rhythm Society, Mai 2017, Chicago, USA. / 83th Annual Meeting of the German Society of Cardiology, April 2017, Mannheim, Germany. Oral presentation.

J. Brado, M.J. Dechant, M. Menza, A. Komancsek, J. Geiger, B. Stiller, D. Foell, B.A. Jung, C. Bode, K.E. Odening. Phase contrast MRI reveals regional, transmural, and apico-basal dispersion of mechanical dysfunction in LQTS patients. 38th Annual Scientific Sessions of the Heart Rhythm Society, Mai 2017, Chicago, USA. / 83th Annual Meeting of the German Society of Cardiology, April 2017, Mannheim, Germany. Oral Presentation.

T. Hornyik, A. Castiglione, G. Franke, S. Perez-Feliz, P. Major, L. Hiripi, G. Koren, Z. Bosze, A. Varro, M. Brunner, C. Bode, I. Baczko, K.E. Odening. Transgenic LQT2, LQT5 and LQT2-5 rabbit models with decreased repolarization reserve as novel tools for more reliable indentification of pro-arrhythmic markers. International Academy of Cardiovascular Science, Oktober 2016, Marseille, France. Best Translational Poster Award / 83th Annual Meeting of the German Society of Cardiology, April 2017, Mannheim, Germany. Oral Presentation.

2016

T. Hornyik, A. Castiglione, G. Franke, S. Perez-Feliz, P. Major, L. Hiripi, G. Koren, Z. Bosze, A. Varro, M. Brunner, C. Bode, I. Baczko, K.E. Odening. Combined use of transgenic LQT2, LQT5 and LQT2-5 rabbit models with decreased repolarization reserve as novel tool for pro-arrhythmia research. European Society of Cardiology meeting, August 2016, Rome, Italy.

T. Hornyik, A. Castiglione, G. Franke, S. Perez-Feliz, P. Major, L. Hiripi, G. Koren, Z. Bosze, A. Varro, K.E. Odening*, I. Baczko*. Cardiac electrophysiological characterization of a novel double-transgenic LQT2-5 rabbit model with decreased repolarization reserve. Hungarian Society of Cardiology meeting, May 2016, Balatonfüred, Ungarn.

S. Koppermann, G. Franke, S. Perez Feliz, D. Ziupa, M. Brunner, G. Koren, M. Zehender, C. Bode, K.E. Odening. Regional Heterogeneities in Ion Channels and Ca2+ Handling Proteins Account for Dispersion of Electro-Mechanical Dysfunction in Transgenic LQT1 Rabbits. “37th Annual Scientific Sessions of the Heart Rhythm Society”, May 2016, San Francisco, USA.

J. Steinfurt, M. Brunner, G. Franke, S. Perez-Feliz, I. Bodi, N.D. Pantulu, C.N. Lang, D. Ziupa, M. Zehender, A. zur Hausen, G. Jolivet, C. Bode, K.E. Odening. In vivo EP Studies in Transgenic Short QT Syndrome Type 1 Rabbits Reveal Shortened Atrial and Ventricular Effective Refractory Periods and Higher Atrial and Ventricular Tachyarrhythmia Inducibility. “37th Annual Scientific Sessions of the Heart Rhythm Society”, May 2016, San Francisco, USA.

J. Steinfurt, J. Biermann, D. Staudacher, D. Dürschmied, L. Trolese, C.N. Nadine Lang, A. Gressler, M. Zehender, T. Faber, C. Bode, K.E. Odening. Clinical and Electrocardiographic Characterization of Familial Form of Early Repolarization Syndrome in Two Siblings. “37th Annual Scientific Sessions of the Heart Rhythm Society”, May 2016, San Francisco, USA.

C. Gloecklhofer, G. Franke, J. Steinfurt, S. Perez-Feliz, M. Brunner, C. Bode, K.E. Odening. A Novel LMNA Nonsense Mutation Causes Familial Dilated Cardiomyopathy with Pronounced Arrhythmogenic Phenotype. “37th Annual Scientific Sessions of the Heart Rhythm Society”, May 2016, San Francisco, USA.

2015

F.F. Dreßler, I. Bodi, M. Menza, S. Perez-Feliz, M. Zehender, C. Bode, J.E. Schneider, J.C. Behrends, G. Seemann, K.E. Odening. Regional Electromechanical Heterogeneity in the Rabbit Wild-Type and Long-QT-Syndrome Heart. “Annual Scientific Sessions of the American Heart Association”, November 2015, Orlando, Fl, USA. Circulation 2015, 132, Suppl:A13021.

F.F. Dreßler, I. Bodi, M. Menza, S. Perez-Feliz, M. Zehender, C. Bode, J.E. Schneider, J.C. Behrends, G. Seemann, K.E. Odening. Cardiac electromechanical heterogeneity as a physiological state – an effort of tying up loose ends from electrophysiology, protein analysis, mechanical MRI and computational modeling. “Annual Meeting of the European Society of Cardiology”, Invitresentationster at Reception of the ESC Council on Basic Cardiovascular Science, Aug/Sept 2015, London, UK.

J. Brado, M.J. Dechant, M. Menza, A. Komancsek, J. Geiger, B. Stiller, C. Bode, B.A. Jung, K.E. Odening. Phase contrast MRI reveals impaired diastolic relaxation and prolonged contraction duration in LQTS patients. “Annual Meeting of the European Society of Cardiology”, Aug/Sept 2015, London, UK.

J. Steinfurt, J. Biermann, F. Scheibe, T. Pottgiesser, I. Hilgendorf, C. Lang, I. Ahrens, T. Wengenmayer, M. Zehender, C. Bode, S. Asbach, T.S. Faber, K.E. Odening. Excessive alcohol intake: a novel trigger for recurrent syncope and electrical storm in early repolarization syndrome. “36th Annual Scientific Sessions of the Heart Rhythm Society”, May 2015, Boston, USA.

K.E. Odening, G. Franke, R. Rieke, A. Topf Aguiar de Medeiros, I. Bodi, S. Perez-Feliz, N.D. Pantulu, C.N. Lang, D. Ziupa, M. Zehender, A. zur Hausen, C. Bode, G. Jolivet, M. Brunner. Transgenic Short QT Syndrome Type 1 Rabbits Mimic the Human Phenotype with Accelerated Cardiac Repolarization, Ventricular Fibrillation and Sudden Death and Exhibit Electro-Mechanical Remodeling. “81th Annual Meeting of the German Society of Cardiology”, April 2015, Mannheim. Oral Presentation.

C.N. Lang, F. Schluermann, J. Steinfurt, K. Schmidt, J. Stuplich, M. Hartmann, J. Biermann, K.E. Odening, T.S. Faber, C. Bode, S. Asbach Wearable Cardioverter Defibrillator (WCD) als Mittel der Risikostratifizierung bei Patienten mit Risikokonstellation für den plötzlichen Herztod. “81th Annual Meeting of the German Society of Cardiology”, April 2015, Mannheim.

J. Brado, M.J. Dechant, M. Menza, A. Komancsek, J. Geiger, B. Stiller, C. Bode, B.A. Jung, K.E. Odening. Klinische Phasenkonstrast-MRT Pilotstudie in LQTS Patienten: Identifikation einer diastolischen Relaxationstörung beim LQTS. “81th Annual Meeting of the German Society of Cardiology”, April 2015, Mannheim. Oral presentation.

F.F. Dreßler, I. Bodi, M. Menza, S. Perez-Feliz, M. Zehender, C. Bode, J.E. Schneider, J.C. Behrends, G. Seemann, K.E. Odening. Regional Heterogeneity in the Rabbit Wild Type and Long QT Syndrome Heart: An Effort of Tying up Loose Ends from Electrophysiology, Protein Analysis, Mechanical MRI and Computational Modeling. “81th Annual Meeting of the German Society of Cardiology”, April 2015, Mannheim.

D. Ziupa, M. Menza, J. Beck, G. Franke, S. Koppermann, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, B.A. Jung, D. Föll, C. Bode, K.E. Odening. Geschlechtsspezifische Unterschiede der QT-Intervalldauer, der regionalen diastolischen Peak-Geschwindigkeit und der regionalen mRNA-Expression von Ca2+-Regulatoren bei transgenen LQT1-Kaninchen. “81th Annual Meeting of the German Society of Cardiology”, April 2015, Mannheim.

2014

K.E. Odening, G. Franke, R. Rieke, A. Topf Aguiar de Medeiros, I. Bodi, S. Perez-Feliz, N.D. Pantulu, C.N. Lang, D. Ziupa, M. Zehender, A. zur Hausen, C. Bode, G. Jolivet, M. Brunner. Transgenic Short QT Syndrome Type 1 Rabbits (HERG-N588K) Mimic the Human Phenotype with Shortened Cardiac Repolarization, Ventricular Fibrillation, and Sudden Death. "Annual Scientific Sessions of the American Heart Association", November 2014, Chicago, IL, USA.

I. Bodi, S.G. Gruenert, U. Spiekerkoetter, M. Zehender, C. Bode, K.E. Odening. Mechanisms of acquired long-QT syndrome in patients with propionic academia. "35th Annual Scientific Sessions of the Heart Rhythm Society", May 2014, San Francisco, CA, USA.

C.N. Lang, S. Jochem, M. Menza, J. Beck, G. Franke, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, B.A. Jung, D. Foell, C. Bode, K.E. Odening. Estradiol Alters Electro-Mechanical Cardiac Function by Prolonging Contraction Duration and Impairing Diastolic Relaxation in Transgenic Long-QT Type 2 Rabbits. 80th Annual Meeting of the German Society of Cardiology, April 2014, Mannheim, Germany.

I. Bodi, S.G. Gruenert, U. Spiekerkoetter, M. Zehender, C. Bode, K.E. Odening. Mechanisms of acquired long-QT syndrome in patients with propionic academia. "80th Annual Meeting of the German Society of Cardiology", April 2014, Mannheim, Germany. Oral Presentation.

J. Sorge*, S.M. Glatz*, G. Franke, I. Bodi, S. Perez Feliz, G. Koren, M. Zehender, M. Brunner, C. Bode, K.E. Odening. Molecular Mechanisms of the Effects of Postpartum Hormones Oxytocin and Prolactin on Cardiac Repolarization in Transgenic Long-QT Type 2 Rabbits. "80th Annual Meeting of the German Society of Cardiology", April 2014, Mannheim, Germany. Oral Presentation.

M. Menza, D. Ziupa, J. Beck, G. Franke, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, B.A. Jung, D. Foell, C. Bode, K.E. Odening. Tissue Phase Mapping analysis of IKr blocker E4031 effects on mechanical cardiac function in transgenic Long-QT syndrome type 1 rabbits. ISMRM, May 2014, Milano, Italy. Summa Cum Laude ISMRM Merit Award.

2013

C. N. Lang, S. Jochem, M. Menza, J. Beck, G. Franke, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, B.A. Jung, D. Foell, C. Bode, K. E. Odening. Gender Differences and Sex Hormone Effects on Electro-Mechanical Cardiac Function in Transgenic Long-QT Type 2 Rabbits. "Annual Scientific Sessions of the American Heart Association", November 2013, Dallas, TX, USA.

S. M. Glatz*, J. Sorge*, G. Franke, I. Bodi, S. Perez Feliz, G. Koren, M. Zehender, M. Brunner, C. Bode, K. E. Odening. Postpartum Hormones Oxytocin and Prolactin Alter Cardiac Repolarization in Transgenic Long-QT Type 2 Rabbits by Affecting IKs Current Densities and Ca2+ Cycling Protein Transcription. "Annual Scientific Sessions of the American Heart Association", November 2013, Dallas, TX, USA.

J. Steinfurt, J. Biermann, M. Hartmann, K. E. Odening, T. S. Faber, C. Bode, S. Asbach. Successful Ablation of Idiopathic Ventricular Fibrillation: Role of Intracardiac Electrocardiograms and Telemedicine. "Herbsttagung der German Society of Cardiology", October 2013, Dresden, Germany. Oral Presentation.

D. Ziupa, M. Menza, J. Beck, G. Franke, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, B. A. Jung, D. Foell, C. Bode, K. E. Odening. E4031 effects on regional electrical and diastolic function in LQT1 rabbits. "34th Annual Scientific Sessions of the Heart Rhythm Society", May 2013, Denver, CO, USA.

D. Ziupa, M. Menza, J. Beck, G. Franke, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, B. A. Jung, D. Foell, C. Bode, K. E. Odening. Der IKr-Blocker E4031 beeinflusst die elektro-mechanischen Funktion in transgenen Long-QT Typ 1 Kaninchen deutlicher als im Wildtyp Kaninchen. "79th Annual Meeting of the German Society of Cardiology", April 2013, Mannheim, Germany. Oral Presentation.

I. Bodi, G. Franke, N. D. Pantulu, K. Wu, S. Perez Feliz, M. Zehender, A. zur Hausen, M. Brunner, C. Bode, K. E. Odening. Differential Ion Channel Blocking Effects of the Beta-Adrenoceptor Blockers Carvedilol and Metoprolol on Short-QT1- and Short-QT2-Mutant Channels. "79th Annual Meeting of the German Society of Cardiology", April 2013, Mannheim, Germany.

2012

K. Kossidas, Z. Zheng, K. E. Odening, M. Zehender, L. Schoffield, S. Taylor, B. Yang, Z. Pfeiffer, B. R. Choi, G. Koren. Progesterone Reduces Isoproterenol-induced pVTs in Male Transgenic Long QT Syndrome 2 (LQT2) Rabbits. "Annual Scientific Sessions of the American Heart Association", November 2012, Los Angeles, CA, USA.

K. E. Odening, B. A. Jung, C. N. Lang, D. Ziupa, G. Franke, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, C. Bode, D. Foell. Spatial Correlation of Action Potential Duration, Contraction Duration, and Diastolic Dysfunction in Transgenic LQT2 Rabbits. "33th Annual Scientific Sessions of the Heart Rhythm Society", May 2012, Boston, MA, USA.

B. A. Jung, D. Foell, C. N. Lang, D. Ziupa, G. Franke, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, K. E. Odening. Correlation between Spatial Differences in Action Potential Duration and Diastolic Dysfunction in Transgenic LQT2 Rabbits. "Annual Meeting of the International Society for Magnetic Resonance in Medicine", May 2012, Melbourne, Australia. Oral Presentation.

B. A. Jung, K. E. Odening, E. Dall'Armellina, D. Foell, J. E. Schneider. A Comprehensive Quantitative Comparison of Myocardial Motion in Mice, Rabbits and Humans using Phase Contrast MRI. "Annual Meeting of Society of Cardiovascular Magnetic Resonance", May 2012, Orlando, Fl, USA.

2011

K. E. Odening, B. A. Jung, D. Ziupa, G. Franke, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, C. Bode, M. Markl, D. Foell. Correlation between Spatial Differences in Action Potential Duration and Diastolic Dysfunction in Transgenic LQT2 Rabbits. "Annual Scientific Sessions of the American Heart Association", November 2011, Orlando, Fl, USA.

K. E. Odening, B-R Choi, G.X. Liu, K. Hartmann, L. Chaves, L. Schofield, M. Brunner, M. Zehender, X. Peng, G. Koren. Mechanisms of Pro-Arrhythmic Effects of Estradiol and Anti-Arrhythmic Effects of Progesterone in Transgenic Long QT Type 2 Rabbit. "77th Annual Meeting of the German Society of Cardiology", April 2011, Mannheim.

M. Hwang, K. E. Odening, B-R. Choi, G. Koren, S.J. Blackband, J.R. Forder. Non-invasive visualization of the complete cardiac conduction system using magnetic resonance microscopy. 2011 SCMR/Euro CMR Joint Scientific Sessions. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):M1

2010

K. E. Odening, B-R Choi, G.X. Liu, K. Hartmann, L. Chaves, L. Schofield, M. Brunner, M. Zehender, X. Peng, G. Koren. Mechanisms of Anti-Arrhythmic Effects of Progesterone and Pro-Arrhythmic Effects of Estradiol in Transgenic Long QT Type 2 Rabbit. "Annual Scientific Sessions of the American Heart Association", November 2010, Chicago, IL, USA. Oral Presentation.

K. E. Odening, O. Ziv, M. Brunner, M. Kirk, P. Lorvidhaya, L. Schofield, L. Chaves, X. Peng, M. Zehender, B.-R. Choi, G. Koren. In vivo Electrophysiological Studies and Optical Mapping of the AV-node/His Region Reveal Genotype-Specific Differences in His Conduction in Transgenic Long QT Type 1 and Type 2 Rabbits. "76th Annual Meeting of the German Society of Cardiology", April 2010, Mannheim.

M. Hwang, K. E. Odening, O. Ziv, B-R. Choi, G. Koren, J.R. Forder. Cardiac Purkinje Fiber Imaging: the first instance of in situ visualization of the conduction path using MR microscopy. "Annual Meeting of the International Society for Magnetic Resonance in Medicine ISMRM", Mai 2010, Stockholm, Schweden. Oral Presentation.

M. Hwang, K. E. Odening, O. Ziv, B-R. Choi, G. Koren, J.R. Forder. Cardiac Diffusion MR Microscopy of Rabbit Heart. "Annual meeting of the International Society for Magnetic Resonance in Medicine ISMRM", Mai 2010, Stockholm, Schweden.

2009

K. E. Odening, B.-R. Choi, M. Brunner, L. Chaves, L. Schofield, M. Zehender, X. Peng, G. Koren. Estradiol's Pro-Arrhythmic and Progesterone's Anti-Arrhythmic Effects in Transgenic Rabbits with Long QT Syndrome 2 are Mediated via Modifications of Cardiac Repolarization and Opposing Effects on Vulnerability to EAD Formation. Northwestern Cardiovascular Young Investigators' Forum, September 2009, Chicago, IL, USA. Oral Presentation and Basic Sciences Award, Runner-Up

K. E. Odening, G.-X. Liu, M. Kirk, M. Brunner, L. Schofield, L. Chaves, M. Zehender, X. Peng, G. Koren. Gender Differences in Remodelling of IKs Account for Gender Differences in Isoproterenol-induced VERP-Shortening and QT/RR Ratio in Transgenic LQT2 Rabbits. "30th Annual Scientific Sessions of the Heart Rhythm Society", Mai 2009, Boston, USA. Heart Rhythm 6 (5S): S100.

K. E. Odening, O. Ziv, B.-R. Choi, L.L. Cooper, L. Chaves, L. Schofield, G. Koren. Aging Slows Conduction in Rabbit His-Purkinje-System and Ventricles and Increases Arrhythmogeneity. "30th Annual Scientific Sessions of the Heart Rhythm Society", Mai 2009, Boston, USA. Heart Rhythm 6 (5S): S236.

K. E. Odening, G-X Liu, M. Kirk, M. Brunner, L. Schofield, L. Chaves, X. Peng, M. Zehender, G. Koren. Longer Ventricular Refractory Periods (VERP) at Baseline and More Pronounced Isoproterenol-induced VERP-shortening in Female LQT2 Rabbits Account for Steeper QT/RR Ratio in Females. "75th Annual Meeting of the German Society of Cardiology", April 2009, Mannheim.

K. E. Odening, O. Ziv, B-R Choi, G-X Liu, M. Kirk, M. Brunner, L. Schofield, L. Chaves, X. Peng, M. Zehender, G. Koren Isoproterenol Reduces Dispersion of Cardiac Refractoriness in Transgenic LQT2 Rabbits. "75th Annual Meeting of the German Society of Cardiology", April 2009, Mannheim.

K. E. Odening, X. Peng, B-R Choi, M. Brunner, L. Chaves, L. Schofield, M. Zehender, G. Koren. Estradiol and Progesterone Exert Opposite Effects on Cardiac Repolarization and Arrhythmogenesis in Transgenic Long QT Syndrome 2 Rabbits. "Biophysical Society 53rd Annual Meeting", Februar/März 2009, Boston, USA. Biophys J. 96 (3 Suppl 1): 563a. Oral Presentation.

2008

O. Ziv, K. E. Odening, M. Kirk, M. Brunner, L. Schofield, L. Chaves, M. Zehender, X. Peng, E. Morales, G. Koren, B.-R. Choi. Sympathetic Stimulation Initiates Dynamic Triggered Activity that Degenerates into pVT and VF in LQT1 Rabbits. "Annual Scientific Sessions of the American Heart Association", November 2008, New Orleans, LA, USA. Circulation 118 (18 Suppl): S530.

K. E. Odening, M. Brunner, L. Chaves, L. Schofield, X. Peng, M. Zehender, M. Kirk, G. Koren. Estradiol and testosterone exert opposite effects on cardiac repolarization in transgenic long QT syndrome 2 rabbits. "29th Annual Scientific Sessions of the Heart Rhythm Society". Mai 2008, San Francisco, USA. Heart Rhythm 5 (S1): S263.

K. E. Odening, O. N. Hyder, L. Chaves, L. Schofield, G. Koren. Transgenic Long QT Rabbits: A Model for Analyzing the Pharmacogenomics of Anesthetic Agents. "29th Annual Scientific Sessions of the Heart Rhythm Society". Mai 2008, San Francisco, USA. Heart Rhythm 5 (S1): S178.

K. E. Odening, O. Hyder, M. Brunner, M. Kirk, P. Lorvidhaya, L. Chaves, L. Schofield, T. Donahay, X. Peng, M. Zehender, G. Koren. Transgenic LQT1 and LQT2 rabbits reveal IKs or IKr blocking properties of drugs in vivo. "74th Annual Meeting of the German Society of Cardiology". März 2008, Mannheim.

K. E. Odening, M. Kirk, M. Brunner, P. Lorvidhaya, G.X. Liu, L. Schofield, L. Chaves, T. Donahay, X. Peng, M. Zehender, G. Koren. Intracardiac In Vivo Electrophysiological Studies in Transgenic LQTS Rabbits Reveal Genotype- and Gender-Differences in Cardiac Refractoriness. "74th Annual Meeting of the German Society of Cardiology". March 2008, Mannheim.

2007

K. E. Odening, M. Brunner, L. Schofield, L. Chaves, X. Peng, M. Zehender, M. Kirk, G. Koren. Estrogen predisposes prepubertal Long QT Syndrome 2 (LQT2) rabbits to cardiac arrhythmias. "Annual Scientific Sessions of the American Heart Association". November 2007, Orlando, FL, USA. Circulation 116 (2007), 16 Suppl. II - 277, 1354.

K. E. Odening, M. Hajjiri, M. Brunner, P. Lorvidhaya, L. Schofield, Peng, M. Zehender, M. Kirk, G. Koren. Gender Differences In Cardiac Repolarization In Transgenic Long QT Syndrome 2 (LQT2) Rabbits. "Annual Scientific Sessions of the American Heart Association" November 2007, Orlando, FL, USA. Circulation 116 (2007), 16 Suppl. II - 277, 1352.

K. E. Odening, M. Kirk, P. Lorvidhaya, M. Brunner, O. Hyder, J. Centracchio, L.Schofield, T. Donahay, L. Chaves, X. Peng, M. Zehender, G. Koren. Transgenic LQT1 and LQT2 rabbits provide a new model for safety screening for IKr or IKs blocking propensity of drugs. 7th Annual Safety Pharmacology Society Meeting. September 2007, Edinburgh, Schottland. J Pharmacol Toxicol Methods. 2008 September - October;58(2):148-149. Poster Award

K. E. Odening, M. Zehender, C. Bode, M. Brunner. First in vivo Electrophysiological Study in Rabbits. The IKr-blocker Ibutilide and the Sympathomimetic Drug Orciprenalin Prolong the Ventricular Refractoriness VERP. "73th Annual Meeting of the German Society of Cardiology". April 2007, Mannheim, Germany.

K. E. Odening, M. Zehender, C. Bode, M. Brunner. Impact of the Elimination of Ito,f on the in vivo Induction of Atrial Fibrillation in Elderly Transgenic Kv4DN Mice."73th Annual Meeting of the German Society of Cardiology", April 2007, Mannheim. Oral Presentation

K. E. Odening, M. Brunner, M. Hajjiri, E. Steinberg, L. Schofield, X. Peng, M. Zehender, M. Kirk, G. Koren. Gender Differences in Cardiac Repolarization in Transgenic LQT Rabbits. "Gordon Research Conference on Cardiac Arrhythmia Mechanisms". March 2007, Ventura, CA, USA

2006

K. E. Odening, R. Macharzina, M. Zehender, C. Bode, M. Brunner. In vivo induction of atrial fibrillation in elderly transgenic mice expressing a dominant negative Kv4.2W362F transgene in the atrial. "World Congress of Cardiology". September 2006, Barcelona, Spanien; Eur Heart J, 27 (Suppl 1): 313-314. Oral Presentation.

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